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In a group of drugs called selective serotonin reuptake inhibitors. Celexa is an antidepressant drug used to treat depression. While Celexa has helped millions, there are still millions who are suffering from depression who could be helped but are too embarrassed to tell a doctor about their condition. Citalopram is primarily used to treat depression. Celexa was shown to be effective in treating post-stroke depression and in alleviating emotional disturbances in elderly consumers with dementia disorders. The treatment of depression. The balance of serotonin, a natural occurring substance found in the brain called serotonin. Celexa is an astonishing antidepressant medication that affects neurotransmitters, the chemical transmitters within the brain.